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26 August 2004


Pharming acquires Patent Portfolio of PPL Therapeutics

QED Intellectual Property Limited (QED) today announced that the Pharming Group N.V. (Euronext: PHARM) (“Pharming”) has acquired a significant patent portfolio from PPL Therapeutics plc (“PPL”). Pharming has acquired these patents to strengthen its product pipeline and protein production technology.

The patents, licence and related know-how cover various products and technologies, including the production and purification of recombinant human fibrinogen and recombinant tissue sealant compositions.

“We are pleased to be able to strengthen our recombinant fibrinogen and recombinant tissue sealant products by acquiring PPL patents and processes, which saves Pharming time and resources in the development of these products”. said Dr. Francis Pinto, CEO of Pharming. “In addition, this transaction significantly advances the worldwide patent position of our protein production technology along with recent agreements with Infigen and ProBio and will allow Pharming to actively pursue licensing and partnering opportunities”.

Also included are patents on the production of recombinant protein products and production technology patents for proteins, fusion proteins, as well as peptides. The patents cover the production of several recombinant proteins, including Alpha-1-Antitrypsin, Factor IX, and others.

Neil Muttock, Managing Director of QED said, “We are pleased to transfer these rights to a company like Pharming, which is a market leader in this sector. PPL having pulled out of this sector, wanted to maximise the value of its remaining assets and we are pleased sell the intellectual property to Pharming who are committed to further investment in this field”.

QED and PPL are both subsidiaries of Innovation Development Limited.


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Key Facts on Patent Portfolio
Pharming has acquired 57 issued patents, including 19 in the US as well as several pending patent applications of PPL Therapeutics.

• Patents and licenses obtained cover the production and purification of human recombinant fibrinogen and recombinant tissue sealant compositions.
• Patents in the portfolio include the production of several recombinant proteins such as Alpha-1-Antitrypsin, Bile Salt Stimulated Lipase, Extracellular Superoxide Dismutase, Alpha-lactalbumin and Factor IX.
• Patents acquired cover the production technology for recombinant proteins, fusion proteins and peptides.
• Pharming has obtained access to processes and know-how for the large scale GMP grade purification of recombinant fibrinogen.


Background on Pharming Group N.V.
Pharming Group N.V. is developing innovative protein therapeutics for unmet medical needs. The Company’s products include potential treatments for genetic disorders and specialty products for surgical indications. Pharming’s lead product for Hereditary Angioedema is in Phase III of clinical development. The advanced technologies of the Company include novel platforms for the production of protein therapeutics, as well as technology and processes for the purification and formulation of these products. Additional information is available on the Pharming website, http://www.pharming.com


For further information please contact:

Europe:
Rein Strijker
Pharming Group N.V.
T: + 31-(0)71-524-7406

USA:
Samir Singh
Pharming Group N.V.
T: + 1-908-720-6224

Neil Muttock
QED Intellectual Property Ltd.
T: + 44 (0) 20 8848 6690


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